Neuroprotective and anti-apoptotic effects of liraglutide on SH-SY5Y cells exposed to methylglyoxal stress
For example, the P5 exenatide analogue is biased to reduce the recruitment of -arrestin, resulting in better long-term hypoglycemic effects than those shown by exenatide, under the precondition that P5 has less cAMP activity
While nutraceuticals are good for health in general and have various advantages including antioxidant, anti-inflammatory, anticancer, etc., the significant disadvantages are underreported as available literature expresses concerns over the authentic source of their raw materials, purity of the compound, presence of other active compounds, quality, lack of experimental evidence, false advertising, contamination with heavy metals, and interactions between supplements and drugs
Moreover, companies are working on the creation of combined therapies and advanced formulations of drugs in order to boost treatment efficacy and improve patients' compliance with treatments