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[16] Although cyanocobalamin lacks a defined upper-toxicity threshold due to its water solubility and renal elimination, exceptionally high cumulative doses have been temporally associated with acneiform eruptions, altered potassium homeostasis, and theoretical thrombotic risk, emphasizing the importance of evidence-based dosing

Ive been using it now for a few months and can definitely tell a difference

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B12 Shots & B12 Injections: Examining the Positives, Negatives, and Ways to Address Negative Reactions