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DAWN2 shines more light on the psychological burden of living with diabetes and on the correlates of quality psychological care
Absolute contraindications include: Active malignancy of any kind (GH and IGF-1 are growth-promoting signals) Active diabetic retinopathy (IGF-1 may worsen retinal vascularity) Pregnancy or breastfeeding Known hypersensitivity to any component of the formulation Pituitary tumours or untreated hypothalamic disease Relative contraindications requiring careful evaluation include pre-existing insulin resistance, type 2 diabetes, uncontrolled cardiovascular disease, and sleep apnoea (GH elevation can worsen upper airway tone in susceptible individuals)
If you are deciding between the two, the choice typically comes down to whether the GIP component of tirzepatide is worth the potentially higher cost and different side effect profile
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