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NrrF is essential for iron homeostasis, is expressed under iron-limiting conditions under the control of Fur and is known to inhibit the translation of sdhA and sdhC mRNAs, which encode subunits of succinate dehydrogenase complex, an iron-containing enzyme

These build up over the years through continual stress, pollution, and other external factors

Of note, all of these patients had the following risk factors: phototype I or II, multiple melanocytic nevi, personal and family history of melanoma, regular use of tanning beds, and repeated exposure to sunlight

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