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Yes, enhanced monitoring is necessary including glucose parameters every 3 months, comprehensive metabolic panels every 36 months, periodic IGF-1 levels, and clinical surveillance for gastrointestinal symptoms, gallbladder disease, and growth hormone-related effects
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3.4 Changes in serum homocysteine by supplementation route and dosage Analysis of 10 comparisons showed that vitamin B12 supplementation was associated with a mean reduction of 35.8% in serum homocysteine concentrations (Supplementary Table S5)
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