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AUC 0 , area under the concentration/time curve from 0 h to infinity
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According to Melanie Palm, MD, board certified dermatologist at Art of Skin MD, Accutane is prescribed when traditional therapies, including topical prescription medications and oral antibiotics or oral anti-androgens, have failed to clear acne. Traditional therapies can fail if any type of acne becomes treatment-resistant to antibiotics over time
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