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In consideration of the reduced compliance of peptide GLP-1 receptor agonists due to subcutaneous injection, oral micromolecular GLP-1 receptor agonists such as orforglipron have already in clinical trials, which can reduce body weight and improve cardiac metabolism in adults with obesity (Wharton et al 2023) (Fig

This step is critical in identifying any imbalances that need to be addressed through therapy

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( PMID: 25545186 ) Ko JW, Park KD, Lee Y, Lee JH, Hong DK (2020) Eosinophilic panniculitis following the subcutaneous injection of exenatide extended-release