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HbA1c in participants with pre-existing pre-diabetes The adjusted mean HbA1c change in ITT participants with pre-diabetes at baseline in the semaglutide group ( n = 2) was 8.0 mmol mol 1 (s.e

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Blocking TGF- signaling genetically (SMAD3 / ) and pharmacologically (anti-TGF- antibody, 1D11) in mice lead to protective effects: decreased body weight gain and fat mass, improved insulin sensitivity, ameliorated hepatic steatosis

Overall, the results of this study indicate that LY3437943 has a safety and tolerability profile similar to other incretins, with pharmacokinetic and pharmacodynamic outcomes that support further clinical evaluation