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The gut microbes have evolved the mechanism of transportation and binding microminerals with high affinity and it is crucial as the levels of bioavailable microminerals necessary for their growth are typically low (90)
A: Multiple pathways: GH receptor upregulation, nitric oxide system modulation, VEGF-promoted angiogenesis, and direct inflammatory cytokine interaction
Vegetarians and vegans represent the highest-risk dietary group, as B12 occurs naturally almost exclusively in animal products
But in living humans, transport is only one step in a long chain
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