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In the SURMOUNT-1 trial, tirzepatide showed significant weight loss results in adults without diabetes over 72 weeks (15-21% body weight reduction, depending on dose), while orlistat typically produces more modest results (approximately 3-5% additional weight loss beyond placebo at 1 year)

While these drugs are a tool, it becomes important to consider who has access to them and the nature of support and care offered to patients taking the medication

But altered intestinal rhythm and the changed handling of fluid and bile acids can just as easily push things the other way, producing looser and more urgent stools