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Although research on the efficacy of these products is still ongoing, they are considered safer than using glutathione alone
This makes it a preferred option for high-risk patients
EudraCT 2021-002318-15JournalNutrientsPublishedJuly 11, 2026PMID42514343DOI10.3390/nu18142274 Clinical Bottom Line This randomized crossover trial found no statistically significant effect of a single Sativex dose on GLP-1, ghrelin, or subjective appetite in older adults with poor appetite, and clinicians should not present appetite stimulation as a proven, mechanism-confirmed benefit of Sativex in this population based on this evidence
However, these observational studies did not establish causality, leaving the causal relationship between T2D and SAundetermined
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