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En cambio, el GLP-1 inhibe la secrecin de glucagn de forma directa, ya que se conoce la presencia del GLP-1R en la clula alfa pancretica, y de forma indirecta al estimular la secrecin de insulina y somatostatina 29

The most common side effects include: Nausea Vomiting Diarrhea Constipation Headache Heartburn Abdominal pain or discomfort These symptoms typically appear during the initiation of medication or during the dose escalation period and subside over time