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Collectively, these extra-hepatic effects create a favorable systemic metabolic environment that indirectly but substantially benefits hepatic steatosis and MASH

Enhanced glycolysis is a key factor driving macrophages toward the pro-inflammatory M1 phenotype

Despite its importance, B12 deficiency is remarkably common particularly among vegetarians, older adults, individuals with digestive conditions, and anyone whose body has difficulty absorbing this vitamin from food or oral supplements