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How These Peptides Work in the Body CJC 1295 stimulates pituitary GH release via GHRH receptors, ipamorelin acts on ghrelin receptors to independently trigger GH secretion, and retatrutide simultaneously activates GLP-1, GIP, and glucagon receptors to reduce appetite and increase energy expenditure

Synergistic Mechanism of Action: When combined, Tesamorlin and Ipamorelin may provide a multi-pathway approach to GH stimulation, enhancing the understanding of pulsatile hormone release, GH receptor sensitivity, and metabolic feedback loops in laboratory models