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The Ames dwarf gene is required for Pit-1 gene activation
The funding sources had no role in the design and conduct of the study
While L-carnitine is available from food sources particularly red meat and dairy products it is also widely used as a dietary supplement in capsule or liquid form
The accumulated data support a multifactorial explanation: cardiometabolic burden is reduced, while the rapid separation of MACE event curves in placebo-controlled trials within months and before substantial weight loss together with imaging evidence for plaque stabilization and reduced coronary inflammation, plausibly support a contribution from direct vascular anti-inflammatory and endothelial mechanisms [9], [24], [25]
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