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In this sense, it is important that pharmacological treatment of T2DM provides not only glycemic control, but also cardiovascular safety and clinically sound benefits in terms of reducing cardiovascular events
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Semaglutides reduce insulin resistance by binding to and activating the GLP-1 receptor, which stimulates insulin secretion and lowers glucagon secretion when blood glucose levels are high
An -aminoisobutyric acid (Aib) residue replaces alanine at position 8, the site where dipeptidyl peptidase-4 normally cleaves and inactivates the native hormone
