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Metabolic Support: Some peptides, including tirzepatide, target GIP receptors that influence fat storage and energy metabolism
During the off-period, the physiological changes initiated by the peptides continue to consolidate
If you go the cycling route, the off periods require aggressive lifestyle management
There is no trial data mandating a specific time of day, but the STEP 5 long-term extension noted that most GI events occurred early in each dose-escalation phase, supporting the logic of extra dietary caution in the 48-hour post-injection window
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