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1) Cancer and Thyroid Concerns Semaglutide is also not recommended for people with a family or medical history of medullary thyroid carcinoma (MTC), medullary thyroid cancer, and thyroid tumors or those with Multiple Endocrine Neoplasia syndrome type 2

When they stop smoking their metabolism slows down leading to weight gain

Joint discomfort may result from indirect factors such as rapid weight loss altering biomechanical loading, nutritional deficiencies from reduced caloric intake, changes in physical activity patterns, or coincidental conditions like osteoarthritis common in the patient demographic