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Additionally, the peptide might have reactivated the apoptosis pathway, a type of programmed cell death crucial for removing faulty cells, as evidenced by activity in caspases 3 and 7, which are enzymes that play key roles in apoptosis

For example, RNP pH triggers nanoparticle disassembly in an acidic microenvironment through protonation of amino groups, releasing TEMPO radicals to significantly reduce BUN and Cr levels, mitigate tissue damage, and suppress inflammatory responses (e.g., decreased IL-6)