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Rosen said the data suggests the impact on the bone is more extensive than we thought and noted that pharmaceutical companies are already working on newer versions of the drugs designed to mitigate bone loss

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This is a secondary-prevention result, not a general heart-health claim, and it belongs to the full obesity dose

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Maintenance phase (weeks 5+): Reduced frequency to 3-5 times per week, with adjusted dosages

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More pronounced indicators warrant immediate attention: panic attacks, uncontrollable trembling, severe insomnia despite fatigue, or intrusive thoughts that disrupt daily function

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