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Notably, in addition to B16-OVA melanoma tumors, the anti-tumor effects of inulin were also confirmed in tumor models of MCA205 fibrosarcoma and MC38 colorectal cancer (CRC) cell lines, and such effects were associated with the response of Th1 cells (69)

Studies have suggested that increased susceptibility to KBD in selenium-deficient populations might result from a reduced antioxidant protection associated with polymorphisms in GPX genes (60, 61), but polymorphisms in other genes have also been implicated (62)

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