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We employ a pancreatic -cell specific EGFR null mouse (-EGFR fx/fx ) and exogenous exendin-4 treatment to show a role for -cell EGFR in -cell mass, islet size, -cell proliferation, and insulin content

Dysesthesia Across Trials TRIUMPH-4 revealed dysesthesia (tingling, burning, or numbness) in 20.9% of participants at 12mg (8.8% at 9mg), versus 0.7% placebo

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While individual GLP-1 receptor agonists may vary in their specific applications (some are approved primarily for diabetes, others for chronic weight management), their core mechanism of action offers a powerful approach to supporting weight loss efforts