While cell death (loss of RBCs) under normal conditions can lead to anaemia, loss of infected RBCs can lead to reduced parasitaemia and protection against malaria
It also is evidenced to cross the blood-brain barrier and is nearest in efficacy to IV glutathione than any other oral form
5-Amino-1MQ is a substrate-mimetic inhibitor occupying the nicotinamide binding site, with a reported IC of 1.2 0.1 M (Neelakantan et al., J Med Chem, 2017)
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