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Investigations into Fat Distribution and Energy Balance Studies on Tesamorelin have suggested possible influences on visceral adiposity, while Ipamorelin and CJC-1295 have been associated with research into energy balance and adiposity distribution
When used for weight management, the evidence increasingly supports long-term or indefinite treatment for patients who respond well and tolerate the medication particularly those with obesity-related cardiovascular risk factors
Age represents a significant variable, as older adults naturally experience sarcopenia (age-related muscle loss) and may have reduced capacity for muscle protein synthesis
Since then, this has been reaffirmed and expanded on in repeated peer-reviewed clinical studies
