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The interaction of copper(II) and glycyl-L-histidyl-L-lysine, a growth-modulating tripeptide from plasma
They found that this tetrapeptide (just four amino acids: Ala-Glu-Asp-Gly) could extend the lifespan of laboratory animals by 20-40% and restore function to aging tissues
Mechanistically, oxidative stress activates p16-pRb effector pathway which is thought to play a vital role in SIPS mediation 11
Trends Pharmacol Sci Sep (2017) 38(9):794808
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