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Unequivocally, we do not see the same effects in humans as we do in rodents, says Elizabeth Pearce, MD, an endocrinologist and thyroid specialist at Boston Medical Center

Oral semaglutide 2550 mg produces the largest average reduction, followed by orforglipron closely behind ( Nausea and vomiting increase with higher semaglutide exposure, with the 50 mg oral dose showing the greatest frequency, especially during dose escalation