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Crucially, several of these effects appear independent of weight loss, strengthening the argument that GLP-1s promote direct neurobiological benefits for brain health and dementia prevention

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Patients on the placebo lost an average of 1% of their starting weight

GLP-1(936) inhibits glucagon secretion equally regardless of stimulus The finding that GLP-1(936) retains its glucagonostatic capacity in the presence of 8-Br-Rp-cAMPS suggests that this action is not mediated by inhibition of PKA