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Starting slowly, protecting the skin barrier, and reporting any ongoing irritation helps keep users safe

102 A placebo-controlled trial that included 54 overweight men with vitamin D deficiency participating in a weight loss program found 3,332 IU (83.3 mcg) of vitamin D daily for one year increased total testosterone (from 10.7 to 13.4 nmol/L [309 to 386 ng/dL]), bioavailable testosterone (from 5.21 to 6.25 nmol/L [150 to 180 ng/dL]), and free testosterone levels (from 0.222 to 0.267 nmol/L [6.4 to 7.7 ng/dL]), whereas placebo led to no significant changes in testosterone levels

Alternating between multiple sites on abdomen, thighs, or other areas distributes tissue stress

Any new compound can cause nausea, cramping, or loose stools in some people