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This study identified a small molecule that activates GSDMD without cleavage, which induces cancer cell pyroptosis and stimulates antitumour immunity

For a stamping treatment, Centella is exactly the kind of soothing, barrier-supporting active you want alongside the deeper actives

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Among the numerous partners that interact with NRF2 regulating its activity, two members of the CNC-bZIP protein family BTB and CNC homolog 1 (BACH1) and BTB and CNC homolog 2 (BACH2) are two negative regulators of NRF2: they compete with NRF2 for the binding to ARE sequences of target genes, thereby preventing the production of antioxidant enzymes and cellular defense against toxicity [232, 233]