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Jun 1995 Patent for extending-4 granted Nov 1995 Tumour cell line secreting GLP-1 shown to suppress appetite in rats 1996 Long-lasting GLP-1 analogue patented 4 Jan 1996 GLP-1 shown to control appetite in the brain 1997 Weight loss drug, Redux, withdrawn from market 24 Mar 1997 US patent 5,614,492 granted to Massachusetts General Hospitalfor use of GLP-1 (7-37) for diabetes mellitus 1 Feb 1998 GLP-1 shown to control appetite in healthy humans 9 Mar 2002 Infusions of GLP-1 reported to lower blood glucose in patients with severe type-2 diabetes 28 Sep 2004 US Patent 5,614,492 for use of GLP-1 (7-36) for diabetes mellitus amended to include Svetlana Mojsov May 2005 First slow-release GLP-1 mimic drug approved for market Oct 2006 First DPP-4 inhibitor drug approved for treating type-2 diabetes 2010 Liraglutide approved for treatment of type-2 diabetes 20 Oct 2013 Drug candidate targeting GLP-1 and GIP shown to reverse obesity and insulin resistance in animals Dec 2014 FDA approved liraglutide for treatment of obesity 2 Jul 2015 Liraglutide found to be promising treatment for obesity in randomised control trial 28 Jul 2016 Post-marketing study shows liraglutide reduces cardiovascular disease in patients with type 2 diabetes Dec 2017 Second GLP-1 drug, semaglutide, approved in US for treatment of obesity Dec 2019 First oral form of GLP-1 drug approved for obesity 8 Apr 2021 Pilot randomised control trial reported exanatide facilitates smoking cessation May 2022 First dual agonist GLP-1 drug approved for diabetes 6 Sep 2022 Randomised, placebo-controlled clinical trial showed once weekly exenatide promising treatment for alcohol addiction Nov 2023 Tirzepatide approved for obesity 18 Dec 2023 The prestigious journal Science names GLP-1 Drugs breakthrough of the year Jan 2024 Semaglutide approved by FDA to help reduce cardiovascular risk in obese patients Dec 2024 Tirzepatide approved by FDA to treat sleep apnea in adults with obesity 7 Apr 2025 GLP-1 drugs found to significantly lower risk of dementia 17 Apr 2025 Daily GLP-1 pill reported to be promising in clinical trial for weight loss and treating type 2 diabetes Science links: Science home | 3D Genomics | AI in biomedical science | Cancer immunotherapy | CRISPR-Cas9 | DNA | DNA extraction | DNA polymerase | DNA Sequencing | Epigenetics | Faecal microbiota transplant | Gene therapy | GLP-1 | Immune checkpoint inhibitors | Messenger RNA (mRNA) | Monoclonal antibodies | Nanopore sequencing | Organ-on-a-chip | p53 Gene | PCR | Phage display | Phage therapy | Plasmid | Protein folding | Recombinant DNA | Restriction enzymes | Stem cells | The human microbiome | Transgenic animals |

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