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It acts by reoxidising protein disulfide isomerase (PDI), the enzyme catalyzing disulfide formation

The oxidized form of guanine, 8-oxo-2-deoxyguanosine (8-oxo-dG), is a valuable marker of oxidative DNA damage during carcinogenesis (116, 117)

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Grapes are a source of polyphenols, proanthocyanidins, and resveratrol, all of which modulate oxidative stress and have been studied in a wide range of health conditions, including high blood pressure, cancer, and Alzheimer disease (Pasinetti 2014