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In the development of dulaglutide, alanine at position 8 in the native GLP-1 sequence was substituted with valine, and the peptide was fused to the Fc domain of immunoglobulin G to confer resistance to DPP-4 degradation
The difference is that the branded pens come pre-mixed and are ready to use, while the generic peptide powder needs to be reconstituted (mixed with sterile water) before each injection cycle
There are approved GLP-1 drugs for managing Type 2 diabetes in kids older than 10
References NQin PP, Wang ZQ, Liu L, et al
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