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In the single-dose study, subjects received 10 mg oral semaglutide with 50 or 240 mL water while fasting, AUC 0-24h and C max were approximately 70% higher when dosed with 50 versus 240 mL water

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Assays were performed at 37C without phosphodiesterase inhibitors, except for with INS-1 832/3 and MIN6B1 cells, where 3-isobutyl-1-methylxanthine (IBMX) was added at 500 M

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