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Green tea EGCG inhibits DNMTs leading to hypomethylation of the tumour suppressor gene promoters (e.g., p16, RAR) and re-expression of pro-apoptotic genes as well as it interferes with RTK signalling NF-B activation that are associated with inflammatory and proliferative signals (16)

(Cianfarani, 2019.) On the GH-IGF-1 axis and tumor growth GH controls IGF-1 production, which happens in the liver

doi: 10.3389/fphar.2023.1147414 Received 18 January 2023 Accepted 22 February 2023 Published 02 March 2023 Volume 14 - 2023 Edited by Zhihao Liu, Dalian Medical University, China Reviewed by Ral Gonzalez Ojeda, University of Galway, Ireland Hang Liu, University of California, Los Angeles, United States Updates Copyright 2023 Pei, Pan, Wei and Hua

Outside the US, Novartis brought in $1.9 billion from Jakafi sales