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In the ACHIEVE-2 trial (Phase 3, 962 adults with type 2 diabetes on metformin), Orforglipron, a novel small-molecule oral GLP-1 RA went head-to-head against Dapagliflozin, one of the most widely used SGLT2 inhibitors
Semaglutide impacts skeletal muscle to a similar extent as caloric restriction in mice with diet-induced obesity
Hamlet Gasoyan, Ph.D., lead author of the study and a researcher with Cleveland Clinics Center for Value-Based Care Research, said: Our study shows that patients treated for obesity with semaglutide or trizepatide lost less weight on average in a regular clinical setting compared to what is observed in randomized clinical trials
GLP-1s help by: Decreasing appetite, which can lead to weight loss and reduce tongue and neck fat Decreasing airway obstruction Improving lung volume
