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This activates a G-protein-coupled signaling cascade that raises intracellular calcium and triggers growth hormone release

Some even go as far to say that, not only will incremental volumes be lower (as a more significant percentage will be won by orals) but also that orals will cannibalize the existing injectable volumes (so not only not a tailwind to future volumes, but also a headwind to existing volumes)

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It works like this: After you eat, gut peptides begin stimulating insulin secretion in response to the typical rise in blood glucose post-meal