Interestingly, secreted Klotho treatment or cardiac-specific overexpression of GR attenuated cardiac apoptosis due to Klotho deficiency or aging
Only then can oxidative stress act as a true messengersignaling what needs repairrather than a masked problem hidden under exogenous antioxidants
Francisco-Cruz, A, Rocha, P, Reuben, A, Krishnan, S, Das, P, Chen, R, Quek, YK, Li, J, Parra Cuentas, ER, Solis Soto, LM, Barua, S, Jiang, M, Segura Lazcano, R, Chow, CW, Behrens, MC, Gumb, C, Little, L, Fukuoka, J, Kalhor, N, Weissferdt, A, Kadara, HN, Heymach, JV, Swisher, SG , Sepesi, B, Uppore Kukkillaya, AR, Moran, C, Zhang, J, Lee, JJ, Fujimoto, J, Futreal, A, Wistuba, II, Peterson, CB, Zhang, J
separate them by time of day or by minutes if layering