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Out-of-pocket costs through traditional pharmacy channels can reach $1,200 monthly for brand-name semaglutide, placing medically necessary treatment financially out of reach for middle-income families
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In addition, studies have linked GLP-1 receptor agonists to skeletal muscle breakdown
The review further highlights emergent research on "next-generation" therapies with weight-loss efficacy of up to about 24% in clinical trials, approaching weight-loss magnitudes reported in some surgical interventions
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