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Su D, Liu H, Liu T et al (2018) Dynamic SAP102 expression in the hippocampal subregions of rats and APP/PS1 mice of various ages

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Irisin additionally attenuates pathological neovascularization by downregulating VEGFA and inhibiting NF-B and HIF-2 signaling (219, 220), whereas apelin strengthens vascular stability by upregulating tight junction proteins (ZO-1, occludin) and protecting pericytes, thereby limiting vascular leakage (149, 221)