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The glucose-lowering agents metformin and SGLT2is are recommended by the KDIGO 2022 guidelines as first-line therapies in patients with T2D, [18] and all three guidelines recommend a RAAS inhibitor, at the maximum tolerated dose, as a standard of care for patients with T2D and albuminuria [18, 20, 84]
Shedding typically becomes noticeable two to four months after the triggering event and may last for several months before spontaneous recovery
It was not a major reason for discontinuation in the trial, but it represents a side effect category that tirzepatide users do not encounter
Instead, focusing on cooking methods using a lower temperature such as steaming, baking, and stir-frying to help reduce the chances of AGEs being formed
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