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Though this method is not typically used to measure cytokine levels as compared to the more common plasma measurements, it can be an important method of measure due to the short half-life of cytokines and their localization in production, thus many studies have utilized this alternate method ( L-GSH supplementation for 3-months resulted in a significant increase in the levels of IFN- in the PBMCs ( Figure 5B ), but not in plasma ( Figure 5A )