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GSH is exclusively degraded at the extracellular level by cells expressing -glutamyltranspeptidase (GGT), such as those of the hepatobiliary tree and of other organs like the heart, kidney, lungs, pancreas, and seminal vesicles
Yes, it canbut it takes time and consistency
Special population studies, including evaluation in elderly patients, patients with significant comorbidities, and patients with organ dysfunction, would help establish safety profiles for diverse clinical populations
On the upside, it can penetrate the skin better (though 10kDa still counts as big!) and might be able to moisturize the deeper layers of the skin where normal HA cannot get
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