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Studies found an association between markers of quality of life (QoL) and certain intestinal microbes ( Faecalibacterium and Coprococcus ) associated with depression (99, 100)
(Peptide Sciences) FOXO4-DRI is built using a D-retro-inverso peptide topology (using Damino acids, reversed sequence) which makes it highly stable and resistant to proteolysis
Phase II Jastreboff 2023 NEJM: -24.2% at 12mg/48w for retatrutide vs SURMOUNT-1 Jastreboff 2022: -20.9% at 15mg/72w for tirzepatide
Sources Garvey WT, et al
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