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When adverse effects occurred, they were typically mild and transient, with the most common being mild to moderate headaches (similar frequency to placebo groups), minor injection site reactions (redness, slight swelling), and gastrointestinal effects at higher oral doses (nausea, diarrhea)
At the end of the study, final blood samples were taken, and the animals were euthanized by cardiac injection
B12 can also be administered with subcutaneous fluid therapy
These injection-site reactions are generally due to mechanical irritation or microbial contamination
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