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Exenatide exerts direct protective effects on endothelial cells through the AMPK/Akt/eNOS pathway in a GLP-1 receptor-dependent manner
In 2023, tirzepatide under the name Zepbound was FDA-approved for obesity as well, after showing ~48 lbs (~22%) mean weight loss over 72 weeks in a trial (SURMOUNT-2) ( [137] )
10.1186/s10020-024-00783-1 52
Cold fluid also activates temperature sensitive nerve endings that amplify discomfort signals
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