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This triggers protein kinase A-mediated phosphorylation of CREB and the transcription factor Pit-1, which drives both growth hormone gene expression and vesicular GH release
This is mechanistically distinct from exogenous GH administration, which bypasses the feedback system entirely and produces sustained, non-pulsatile elevation
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Salama SA, Arab HH, Omar HA, Gad HS, Abd-Allah GM, Maghrabi IA, et al
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