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Pavli, Polina, et al
Triple-receptor pharmacology preclinical assay endpoints and pathway-specific readouts
The structural technique in-line probing is being utilized to determine whether there is a change in the OAZ RNA structure that is dependent on the presence of a small molecule, specifically the polyamine spermine and related amine-containing compounds
Their evidence base is public: the STEP program studied semaglutide for weight management ( The New England Journal of Medicine , 2021), SURMOUNT studied tirzepatide for weight management (NEJM, 2022), and SURMOUNT-OSA examined tirzepatide in obstructive sleep apnea (NEJM, 2024)
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