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Moreover, KO mice for liver IGF-1 gene developed muscle insulin resistance (it is important to mention that skeletal muscle myocytes express high number of IGF-1R), showing an increase in insulin concentrations and a substantial decrease in the insulin-induced autophosphorylation of the insulin receptor and IRS in skeletal muscle (being normal in liver and white adipose tissue)

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Recommended Storage Guidelines Store lyophilized peptide at -20C or lower Keep vial sealed and protected from direct light Avoid repeated freeze-thaw cycles Use sterile laboratory procedures during handling Refrigerate reconstituted material for short-term laboratory storage if applicable Following proper handling procedures helps preserve peptide quality throughout research use

It is best to refrain from self-diagnosing Vitamin B12 deficiencies