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For instance, in an 8-week randomized controlled trial, tirzepatide treatment significantly reduced LDL cholesterol and C-reactive protein levels in patients with type 2 diabetes ( Given that tirzepatide activates both GLP-1 and GIP signaling pathways, its cardiovascular benefits may arise not only from the effects of GLP-1 but also from the potential effects of GIP

The FDA-approved initial dose is 2.5 mg administered subcutaneously once weekly for the first four weeks