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Co-enzyme B12 also interacts with the enzyme methionine synthase (5-methyltetrahydrofolate-homocysteine methyltransferase), required for the conversion of homocysteine to methionine, which is essential for folic acid metabolism and the formation of thymine, which is a component of DNA

Vitamin B12 deficiencies are therefore quite common among vegetarians and vegans

By synthesizing a molecule that could permeate the cell membrane and selectively inhibit NNMT, researchers discovered they could fundamentally alter the metabolic profile of the cell

More significantly, MOTS-c administration shifted the trajectory of age-related metabolic decline, indicating that the peptide's benefits are not limited to preventing dysfunction in young animals but can partially reverse established decline [2]